Properties

• Amadol (Tramadol) has a dual mechanism of action within the CNS; it exerts agonistic properties at opiate receptors and inteferes with the neurotransmitter reuptake.
• In addition, Amadol inhibits reuptake of norepinephrin and seretonin. It also bind weakly to opiate receptors, blocking the transmission of pain signals to brain.

Indications

It is used for the relief of: back pain, moderate pain, neuropathic pain, orthopedic pain, severe pain and surgical pain.

Dosage & Administration

• For the treatment of moderate pain or severe pain and chronic conditions and cancer pain.
• Adults & adolescents (>16 years): 50-100mg every 4-6 hours, (not exceeding 400mg/day).
• Elderly patients: the maximum daily dose is 300mg, given in divided doses.

Contra-Indications

• Amadol should be used with caution in patients with or at risk of respiratory depression, patients with pre-existing seizure disorders, with GI disease, with increased intracranial pressure or head trauma.
• Not recommended for use in breast feeding women.

Side Effects

• CNS: dizziness, vertigo, headache, drowsiness, anxiety, agitation, tremors, euphoria, insomnia and visual impairment.
• GI: nausea, vomiting, constipation, diarrhea, dyspepsia, xerostomia, abdominal pain and anorexia.
• Urogenital: increased urinary frequency, urinary retention.
• Dermatological: pruritis, rash and urticaria.

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