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| GABITRIL FULL DESCRIPTION |
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How does it work?
Tiagabine is an anti-epileptic medicine that can be used to regulate the activity of nerves.
The brain and nerves are made up of many nerve cells that communicate with each other through electrical signals. These signals must be carefully regulated for the brain and nerves to function properly.
When abnormally rapid and repetitive electrical signals are released in the brain, it becomes over-stimulated and normal function is disturbed. This results in fits or seizures.
GABA is a chemical that, when released in the brain, acts as a natural calming agent and keeps the nerve activity in balance. Once the brain absorbs the GABA (uptake), this chemical can no longer act on the nerves. Too little GABA, the brain may become overexcited.
Tiagabine prevents the uptake of GABA in the brain. This enables GABA to calm nerve cells for a longer period of time. By calming nerve cells, tiagabine prevents excessively rapid and repetitive firing of electrical signals. Thereby electrical nerve activity in the brain is stabilised, leading to prevention of fits and maintenance of normal brain function.
Tiagabine is used to treat epilepsy that has not been well controlled by the use of at least one other anti-epileptic medicine.
What is it used for?
Generalised seizures
Partial seizures
Warning!
This medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
You should not suddenly stop taking this medicine unless your doctor tells you otherwise.
Use with caution in
Decreased liver function
Not to be used in
Children under 12 years of age
Severe liver disease
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
The medicine should not be used during pregnancy or breastfeeding unless considered essential by your doctor. Seek medical advice.
Label warnings
Take this medication with or after food.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Diarrhoea
Tiredness
Shaking, usually of the hands (tremor)
Speech disturbances
Dizziness
Concentration difficulties
Unstable moods (emotional lability)
Nervousness
Depressed mood
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
Tiagabine blood levels may be decreased by:
Carbamazepine
Phenobarbitone
Phenytoin
and primidone.
Tiagabine may slightly decrease the blood levels of sodium valproate. |
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